Table 1.
Baseline features of the overall study patients and the antibiotic-exposed and unexposed groups
| Overall n = 100 |
Unexposed group n = 77 |
Exposed group n = 23 |
p value | |
|---|---|---|---|---|
| Age (years), median [IQR] | 58 [50–68] | 59 [50–68] | 57 [52–61] | 0.371 |
| Male sex, n (%) | 63 (63) | 47 (61) | 16 (70) | 0.623 |
| BMI (kg/m2), median [IQR] | 28 [23–34] | 27 [22–32] | 30 [26–35] | 0.102 |
| Localization: limbs, n (%) | 52 (52) | 38 (49) | 14 (61) | 0.353 |
| Localization: pelvis, n (%) | 15 (15) | 11 (14) | 4 (17) | 0.743 |
| Localization: cephalic, n (%) | 23 (23) | 21 (27) | 2 (9) | 0.09 |
| Localization: trunk, n (%) | 13 (13) | 8 (10) | 5 (22) | 0.169 |
| Skin surface (%), median [IQR] | 4.5 [4.5–9] | 4.5 [4.5–9] | 4.5 [4.5–9] | 0.597 |
| SAPS-II score on admission, median [IQR] | 28 [23–37] | 28 [23–37] | 25 [21–36] | 0.287 |
| SOFA score on admission, median [IQR] | 5 [3-6] | 5 [3-6] | 4 [3-7] | 0.977 |
| LRINEC score on admission, median [IQR] | 2 [1-4] | 2 [0–4] | 3 [2-5] | 0.118 |
| Septic shock on admission, n (%) | 65 (65) | 51 (66) | 14 (61) | 0.628 |
| Charlson score on admission, median [IQR] | 4 [3-7] | 3 [2-6] | 3 [2-6] | 0.758 |
| Underlying medical conditions | ||||
| Malignancy, n (%) | 23 (23) | 20 (26) | 3 (13) | 0.264 |
| Obesity, n (%) | 24 (23) | 16 (21) | 7 (30) | 0.399 |
| Diabetes mellitus, n (%) | 24 (24) | 17 (22) | 7 (30) | 0.415 |
| Coronary disease, n (%) | 20 (20) | 14 (18) | 6 (26) | 0.553 |
| Peripheral vascular disease, n (%) | 17 (17) | 13 (17) | 4 (17) | 1 |
| Alcohol use, n (%) | 20 (20) | 16 (21) | 4 (17) | 1 |
| Active smoking, n (%) | 54 (54) | 42 (55) | 12 (52) | 1 |
| Immunosuppression, n (%) | 10 (10) | 8 (10) | 2 (9) | 1 |
BMI body mass index, LRINEC Laboratory Risk Indicators for Necrotizing Fasciitis score, SAPS-II Simplified Acute Physiology Score-II, SOFA sequential organ failure assessment