Fig. 6.

GSK induced increase of TRPV4 current densities (pA/pF) in the SH-SY5Y cells but not in the HEK293 cells. The modulator role of CARV. (Mean ± STD and n=3-6). The TRPM2 currents were induced in the SH-SY5Y cells by the stimulation of GSK (100 nM), but they were blocked by the treatment of CARV (100 µM). W.C.: The record of whole cell. a. Cntr (without GSK). b. Cntr (with GSK and RuRe). c. GSK+CARV (100 µM). d. GSK + RuRe and GSK + CARV (1 h). e. HEK293 cells + ADPR (without TRPM2). f. The mean currents densities of TRPM2 in the SH-SY5Y and HEK293 cells after the treatments of GSK, RuRe, and CARV (^ͼp ≤ 0.05 vs. Cntr. ©p ≤ 0.05 vs. GSK)