Table 4.
Prognostic role of non-invasive ischaemia testing in patients with prior coronary artery bypass graft surgery.
| References* | Study design | Imaging modality | Stressor | Number of patients | Male (%) | Follow up (months) | Study result |
|---|---|---|---|---|---|---|---|
| Cortigiani et al. (121) | Observational, multicenter | Stress echo | Dipyridamole | 349 | 77 | 22 | Ischemia associated with prognosis. CFVR of LAD ≤ 2 associated with HR 2.28 |
| Harb et al. (122) | Observational, single center | Stress echo | Exercise | 962 | 88 | 69 | Ischaemia predicted mortality (HR 2.10) |
| Cortigiani et al. (123) | Observational, single center | Stress echo | Dobutamine Exercise Dipyridamole |
500 | 80 | 25 | Peak wall motion score index predicted mortality and MI (HR 3.07) |
| Arruda et al. (124) | Observational, single center | Stress echo | Exercise | 718 | 82 | 35 | 18% reduction in hazard for every 10% incremental increase in exercise LVEF |
| Ortiz et al. (22) | Observational, single center | SPECT | Exercise Adenosine |
84 | 100 | 119 | Defect size 1 year following CABG, predicted death and CHF |
| Acampa et al. (110) | Observational, single center | SPECT | Dipyridamole Exercise |
362 | 90 | 26 | SPECT performed 5 years after CABG predicted death and MI (HR 3.7). |
| Sarda et al. (111) | Observational, single center | SPECT | Dipyridamole Exercise |
115 | 90 | 35 | Extent of stress defect predicted cardiac death and MI |
| Shapira et al. (112)* | Observational, single center | SPECT | - | 170 | - | 48 | SPECT performed soon after CABG has prognostic value |
| Palmas et al. (125) | Observational, single center | SPECT | Exercise | 294 | 86 | 31 | Incremental prognostic information provided by SPECT |
| Miller et al. (126) | Observational, single center | SPECT | Exercise | 411 | 80 | 70 | Exercise Tl-201 imaging performed within 2 years of CABG predicts outcomes |
| Lauer et al. (127) | Observational, single center | SPECT | Exercise | 873 | 91 | 36 | Exercise capacity and perfusion defects predict death (HR 2.78) in asymptomatic patients |
| Zellweger et al. (128) | Observational, single center | SPECT | Adenosine Exercise |
1,765 | 80 | 23 | MPS is strongly predictive of subsequent adverse events |
| Pen et al. (129) | Observational, multi-center | PET | Site-specific | 953 | 70.8 | 29 | Summed stress score predicted mortality (HR1.6) and cardiac death (HR1.8) |
| Kinnel et al. (130) | Observational, single center | CMR | Dipyridamole | 852 | 89 | 50.4 | Ischaemia predicted CV death (HR 2.15) |
SPECT, Single-Photon Emission Computed Tomography; CMR, Cardiac Magnetic Resonance; PET, Positron Emission Tomography; HR, hazard ratio; MI, myocardial infarction; CHF, Congestive heart failure.
*
Abstract available only.