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. 2021 Dec 18;25(1):103650. doi: 10.1016/j.isci.2021.103650

Figure 3.

Figure 3

THPP series activity in biochemical assays

(A) BIO-2007817 structure and TR-FRET concentration response curve.

(B and C) (B) Parkin autoubiquitination and (C) Miro1 ubiquitination induced by increasing concentrations of BIO-2007817. W403A-Parkin is shown as a positive control.

(D) BIO-2007818 structure and concentration response curve.

(E and F)(E) Parkin autoubiquitination and (F) Miro1 ubiquitination induced by increasing concentrations of BIO-2007818. (G) BIO-1984542 structure and concentration response curve.

(H and I) (H) Parkin autoubiquitination and (I) Miro1 ubiquitination induced by increasing concentrations of BIO-1984542. Concentration response curves represent n = 2 technical replicates. Western blots represent n = 1 biological replicates. See also Table 1.