TABLE 1.

miRNAs associated with neuropathic pain.

Models	miRNAs	Expression	Tissue	Target gene	References
pSNL	miR-23a-3p	↓	Spinal glial cells	CXCR4 TXNIP/NLRP3	Pan et al., 2018
CCI	miR-381	↑	Spinal cord tissues	HMGB1/CXCR4	Zhan et al., 2018
SNL	miR-186-5P	↓	Spinal astrocyte	CXCL13	Jiang et al., 2016
SNL	miR-103	↓	Spinal cord	Cav1.2-LTC	Favereaux et al., 2011
SNL	miR-17-92	↑	DRG	Voltage-gated potassium channel	Sakai et al., 2017
SNL	miR-7a	↓	DRG	Voltage-gated sodium channel	Sakai et al., 2013
SNL	miR-30b	↓	DRG/spinal cord	Voltage-gated sodium channel Nav1.3	Su et al., 2017
NP patients	miR-124a, miR-155	↑	Blood samples	SIRT1	Heyn et al., 2016
SNL	miR-183	↓	L5 DRG	T-Cell intracellular antigen 1 (TIA-1)	Aldrich et al., 2009
SNL	miR-21, miR-431, miR-511-3p	↑	DRG	IL-6	Hori et al., 2016
CCI	miR-146a-5p	↑	DRG/SDH	IRAK1/TRAF6	Wang Z. et al., 2018
SNL	miR-146a-5p	↑	Spinal cord	TRAF6/JNK	Lu et al., 2015
SCI	miR-218	↓	Spinal cord	SOCS3/p-P38	Li and Zhao, 2016
CCI	miR-221	↑	Spinal cord	SOCS1	Xia et al., 2016
CCI + tolerance morphine	miR-223	↓	Spinal cord	NLRP3	Xie X.J. et al., 2017
CCI	miR-34c	↓	Spinal cord	NLRP3	Xu et al., 2019
CCI	miR-26a-5p	↓	Spinal cord	MAPK6	Zhang et al., 2018a
CCI	miR-1	↓	SN/DRG	Cx43/BDNF	Neumann et al., 2015
SNI	miR-30c-5p	↑	Spinal cord/DRG/plasma/fluid cerebrospinal	BAMBI	Tramullas et al., 2018
DNP	miR-190a-5p	↓	Spinal dorsal horn	SLC17A6	Yang et al., 2017
DNP	miR-193a	↓	Spinal dorsal horn	HMGB1	Wu B. et al., 2019
DNP	miR-221	↑	Serum	SOCS3	Wu et al., 2021
DPNP	miR-590-3p	↓	DRG/T cells	RAP1A	Wu et al., 2020
SCI	miR-130a-3p	↑	Spinal cord	IGF-1/IGF-1R	Yao et al., 2021
CCI	miR-378	↓	Spinal cord	EZH2	Gao et al., 2021
pSNL	miR-138	↑	Spinal cord	TLR4 MIP-1a/CCR1	Jin et al., 2021
CCI	miR-223	↓	Spinal cord	NLRP3/IL-1β	Zhu et al., 2021
CCI	miR-122-5p	↓	Spinal cord	PDK4	Wan et al., 2021
CCI	miR-142-3p	↑	Sciatic nerve	cAMP/AMPK	Li et al., 2021
NP patients/SNI	miR-132-3p	↑	White blood cells/SN/DRG/Spinal cord	GluA1/GluA2	Leinders et al., 2016
CCI	miR-200b/miR-429	↑	Microglia from the Spinal cord	ZEB1	Yan et al., 2018c
SNI	CREB-miR-132	↓	Spinal cord	MeCP2	Zhang et al., 2015
CCI	miR-183	↓	Spinal cord horn	mTOR/VEGF	Xie X. et al., 2017
Oxaliplatin-induced NP	miR-30b-5p	↓	DRG	Nav1.6	Li L. et al., 2019
Oxaliplatin-induced NP	miR-15b	↑	DRG	BACE1	Ito et al., 2017
L5 ventral root transection/paclitaxel-induced NP	miR-500	↑	Spinal cord horn	GAD67	Huang et al., 2016
SCI	miR-23b	↓	Spinal cord	NOX4	Im et al., 2012
CCI	miR-183	↓	Spinal cord horn	MAP3K4/IL-6/IL-1β/COX2	Huang et al., 2020
SNI	miR-21	↑	DRG	TLR8	Zhang et al., 2018c

NP, Neuropathic pain; DRG, dorsal root ganglion; pSNL, partial sciatic nerve ligation; SNL, sciatic nerve ligation; SNI, spared nerve injury; CCI, chronic constriction injury; SCI, spinal cord injury; DNP, diabetic neuropathic pain; CXCR4, chemokine CXC receptor 4; TXNIP, thioredoxin-interacting protein; NLRP3, NOD-like receptor protein 3; HMGB1, high-mobility group box 1 protein; CXCL13, C–X–C motif chemokine 13; Cav1.2-LTC, L-type calcium channel; SIRT1, sirtuin1; SDH, spinal dorsal horn; IRAK1, inhibiting interleukin-1 receptor-associated kinase 1; TRAF6, tumor necrosis factor receptor-associated factor 6; SOCS3, suppressor of cytokine signaling 3; SN, sciatic nerve; BDNF, brain-derived neurotrophic factor; Cx43, connexin 43; BAMBI, bone morphogenetic protein and membrane-bound inhibitor; ZEB1, zinc finger E box binding protein-1; MeCP2, methyl CpG-binding protein 2; NOX4, NADPH oxidase 4; TLR8, toll-like receptor 8; IL-1β, interleukin-1β; PDK4, pyruvate dehydrogenase kinase 4; RAP1A, Ras-associated protein 1A; SLC17A6, [solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6]; MIP-1α, macrophage inflammatory protein-1 alpha and CCR1, C–C chemokine receptor type 1; AMPK, AMP-activated protein kinase; EZH2, enhancer of zeste homolog 2; BACE1, β-site amyloid precursor protein-cleaving enzyme 1.