TABLE 2.
lncRNAs associated with neuropathic pain.
| Models | lncRNA | Expression | Tissue | Target gene | References |
| SNL | Kcna2 antisense RNA | ↑ | DRG | Myeloid zinc finger protein 1 | Zhao et al., 2013 |
| DNP | lncRNA BC168687 | ↑ | DRG | TRPV1 | Liu C. et al., 2018 |
| DNP | lncRNA BC168687 | ↑ | SGCs of DRG | P2 × 7 | Liu C.L. et al., 2018 |
| DNP | lncRNA NONRATT021972 | ↑ | DRG | P2 × 7 | Liu et al., 2016 |
| DNP | lncRNA uc 0.48 + | ↑ | DRG | P2 × 3/p-ERK1/2 | Wang et al., 2016 |
| DNP | lncRNA NONRATT021972 | ↑ | Blood | TNF-a | Yu et al., 2017 |
| SCI | lncRNA PVT1 | ↑ | Spinal cord | miR-186-5p/CXCL13/CXCR5 | Zhang P. et al., 2021 |
| SCI | lncRNA NEAT1 | ↑ | Spinal cord | miR-128-3p/AQP4 | Xian et al., 2021 |
| TN | lncRNA uc 0.48 + | ↑ | Trigeminal ganglia | P2 × 7/p-ERK1/2 | Xiong et al., 2019 |
| CCI | lncRNA MRAK009713 | ↑ | DRG | P2 × 3 | Li et al., 2017 |
| SNL | H19 lncRNA | ↑ | L5 DRG | − | Iwasaki et al., 2019 |
| SNL | lncRNA PKIA-AS1 | ↑ | Spinal cord | CDK6 | Hu et al., 2019 |
| CCI | lncRNA CRNDE | ↑ | L4-L6 dorsal spinal cord | miR-136/IL-6R | Zhang D. et al., 2019 |
| CCI | lncRNA DGCR5 | ↓ | L4-L6 dorsal spinal cord | miR-330-3p/PDCD4 | Peng et al., 2019 |
| CCI | lncRNA XIST | ↑ | L4-L6 dorsal spinal cord | miR-137/TNFAIP1 | Zhao et al., 2018 |
| CCI | lncRNA XIST | ↑ | L4-L6 dorsal spinal cord | miR-544/STAT3 | Jin et al., 2018 |
| CCI | lncRNA XIST | ↑ | L4-L6 dorsal spinal cord | miR-154-5p/TLR5 | Wei et al., 2018 |
| CCI | lncRNA XIST | ↑ | L4-L6 dorsal spinal cord | miR-150/ZEB1 | Yan et al., 2018b |
| CCI | lncRNA 00657 | ↑ | L4-L6 dorsal spinal cord | miR-136/ZEB1 | Shen et al., 2019 |
| CCI | lncRNA MALAT1 | ↑ | L4-L6 dorsal spinal cord | miR-206/ZEB2 | Chen et al., 2019 |
| CCI | linRNA NEAT1 | ↑ | L4-L6 dorsal spinal cord | miR-381/HMGB1 | Xia et al., 2018 |
| CCI | SCN9A | ↑ | L4-L6 ipsilateral DRG | Koenig et al., 2015 |
NP, Neuropathic pain; lncRNAs, long non-coding RNAs; DRG, dorsal root ganglion; SNL, sciatic nerve ligation; CCI, chronic constriction injury; DNP, diabetic neuropathic pain; TN, trigeminal neuralgia; SCI, spinal cord injury; CXCR5, chemokine CXC receptor 5; HMGB1, high-mobility group box 1 protein; CXCL13, C–X–C motif chemokine 13; STAT3, signal transducer and activator of transcription 3; ZEB1, zinc finger E box binding protein-1; TLR8, toll-like receptor 8; ERK, extracellular regulated protein kinases; TRPV1, transient receptor potential vanilloid type 1; P2 × 7, P2X purinoceptor; SGCs, satellite glial cells; L5, lumbar 5; CDK6, cyclin-dependent kinase 6; CRNDE, colorectal neoplasia differentially expressed; XIST, X inactive specific transcript; TNFAIP1, tumor necrosis factor alpha-induced protein 1; TNF-α, tumor necrosis factor-α; IL-6R, interleukin-6 receptor; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; NEAT1, nuclear paraspeckle assembly transcript 1; AQP4, aquaporin-4.