Table 1.
Characteristics of IgAN patients by urinary CD163 tertiles at biopsy.
| Urinary sCD163 (ng/mg Cr) | |||||
|---|---|---|---|---|---|
| Variable a | Overall | T1 (<1.27) | T2 (1.27-3.57) | T3 (＞3.57) | P b |
| No. of patients | 349 | 116 | 117 | 116 | – |
| Age, y | 40.95 ± 12.73 | 40.59 ± 12.47 | 39.45 ± 12.01 | 42.80 ± 13.54 | 0.125 |
| Male | 191 (54.7%) | 78 (67.2%) | 63 (53.8%) | 50 (43.1%) | 0.001 |
| BMI, kg/m2 | 24.33 ± 3.63 | 24.65 ± 3.30 | 24.01 ± 3.79 | 24.32 ± 3.79 | 0.409 |
| Hypertension | 178 (51.0%) | 58 (50.0%) | 58 (49.6%) | 62 (53.4%) | 0.811 |
| Diabetes | 17 (4.9%) | 7 (6%) | 3 (2.6%) | 7 (6%) | 0.364 |
| MAP, mmHg | 98.83 ± 11.84 | 97.03 ± 10.72 | 99.65 ± 12.18 | 99.82 ± 12.42 | 0.131 |
| Hemoglobin, g/L | 128.55 ± 19.46 | 134.82 ± 17.40 | 129.32 ± 20.05 | 121.63 ± 19.68 | <0.0001 |
| Serum albumin, g/L | 39.04 ± 4.74 | 41.03 ± 3.44 | 39.79 ± 4.08 | 36.33 ± 5.24 | <0.0001 |
| CRP, mg/dL | 0.20 ± 0.38 | 0.17 ± 0.34 | 0.21 ± 0.41 | 0.23 ± 0.37 | 0.437 |
| Serum creatinine, mg/dL | 1.28 ± 0.65 | 1.13 ± 0.40 | 1.27 ± 0.60 | 1.43 ± 0.83 | 0.002 |
| eGFR, mL/min/1.73m2 | 74.35 ± 29.35 | 81.97 ± 25.56 | 74.51 ± 28.36 | 66.59 ± 31.98 | <0.0001 |
| Proteinuria, g/24h | 1.47 ± 1.22 | 0.75 ± 0.63 | 1.33 ± 0.96 | 2.33 ± 1.36 | <0.0001 |
| Urinary IL6, ng/mg Cr | 54.38 ± 65.54 | 30.10 ± 28.27 | 51.94 ± 63.41 | 80.91 ± 82.51 | <0.0001 |
| Urinary MCP-1, ng/mg Cr | 561.90 ± 501.73 | 331.60 ± 316.51 | 508.65 ± 368.80 | 843.92 ± 622.03 | <0.0001 |
| Use ACEI/ARBs at biopsy | 78 (22.3%) | 26 (22.4%) | 30 (25.6%) | 22 (19%) | 0.473 |
| Renal biopsy Lee’s classification | <0.0001 | ||||
| Mild (I-II) | 49 (14.0%) | 32 (27.6%) | 12 (10.3%) | 5 (4.3%) | |
| Moderate (III) | 79 (22.6%) | 34 (29.3%) | 30 (25.6%) | 15 (12.9%) | |
| Severe (IV-V) | 221 (63.3%) | 50 (43.1%) | 75 (64.1%) | 96 (82.8%) | |
| Oxford MEST-C | |||||
| M1 | 302 (86.5%) | 78 (67.2%) | 111 (94.9%) | 113 (97.4%) | <0.0001 |
| E1 | 46 (13.2%) | 7 (6.0%) | 15 (12.8%) | 24 (20.7%) | 0.004 |
| S1 | 191 (54.7%) | 44 (37.9%) | 66 (56.4%) | 81 (69.8%) | <0.0001 |
| T1-2 | 156 (44.7%) | 30 (25.9%) | 53 (45.3%) | 73 (62.9%) | <0.0001 |
| C1-2 | 113 (38.1%) | 17 (14.7%) | 49 (41.9%) | 67 (57.8%) | <0.0001 |
BMI, body mass index; eGFR, estimated glomerular filtration rate; MAP, mean arterial blood pressure; CRP, C-reactive protein; U-MCP-1, urinary monocyte chemoattractant protein-1; ACEI, Angiotensin-converting enzyme inhibitors; ARBs, Angiotensin II receptor blockers; MEST-C, histologic score based on mesangial hypercellularity, the presence of endocapillary proliferation, segmental glomerulosclerosis/adhesion, and severity of tubular atrophy/interstitial fibrosis, and crescents formation; T, tertile.
Continuous variables are expressed as mean ± standard deviation. Categorial variables are expressed as number (percent).
Comparing the covariated across the 3 urinary sCD163 categories.