Table 3.
List of thephysico-chemical properties of selected potential targets
| Potential drug targets | Number of Amino acids | Molecular weight | Isoelectric Point | negatively charged residues | positively charged residues | aliphatic index | Instability index | Extinction coefficient (M−1 cm−1) | GRAVY | Nature |
|---|---|---|---|---|---|---|---|---|---|---|
| Glucose-6-phosphate isomerase | 449 | 49,421.66 | 4.84 | 63 | 45 | 88.69 | 27.26 | 54,780 | − 0.232 | Stable |
| 4-Hydroxy-tetrahydrodipicolinate reductase | 255 | 27,804.82 | 5.07 | 39 | 27 | 69.51 | 20.48 | 239,060 | − 0.063 | Stable |
| Glycogen synthase | 476 | 54,311.80 | 5.69 | 45 | 36 | 87.01 | 32.11 | 7572 | − 0.287 | Stable |
| Glucan-binding protein GbpC | 583 | 63,349.90 | 6.75 | 20 | 20 | 104.93 | 25.67 | 4576 | 0.079 | Stable |
| Cell surface antigen SpaP | 1562 | 169,971.93 | 5.3 | 35 | 31 | 104.52 | 23.72 | 16,008 | − 0.223 | Stable |
| Thiol peroxidase | 161 | 17,552.71 | 5.08 | 36 | 31 | 122.83 | 27.03 | 24,535 | − 0.061 | Stable |
| Levansucrase | 795 | 87,384.68 | 5.8 | 27 | 22 | 93.44 | 21.92 | 13,076 | − 0.114 | Stable |
| Phospho-2-dehydro-3-deoxyheptonate aldolase | 343 | 38,718.65 | 5.53 | 43 | 42 | 77.33 | 39.84 | 22,256 | − 0.455 | Stable |
| ATP synthase F0F1 subunit alpha | 501 | 54,372.84 | 5.42 | 28 | 15 | 7450 | 47.87 | 19,878 | − 0.094 | Unstable |
| ATP synthase F0F1 subunit beta | 689 | 75,218.11 | 4.88 | 45 | 30 | 101.02 | 40.2 | 22,045 | − 0.473 | Unstable |
| Glucosyltransferase-SI | 1455 | 162,966.24 | 5.28 | 41 | 36 | 100.1 | 33.5 | 14,900 | − 0.151 | Stable |
| Glucosyltransferase-I | 1476 | 165,846.81 | 5.09 | 68 | 53 | 103.68 | 30.32 | 25,245 | − 0.16 | Stable |
| secreted antigen GbpB/SagA | 431 | 44,620.42 | 9.46 | 66 | 64 | 94.65 | 27.18 | 17,880 | − 0.219 | Stable |
| Formate acetyltransferase | 775 | 87,605.80 | 5.27 | 49 | 38 | 92.7 | 21.62 | 26,860 | − 0.321 | Stable |
| Fructose-1,6-biphosphate aldolase | 293 | 31,425.80 | 5.46 | 32 | 26 | 99.96 | 31.78 | 13,535 | 0.007 | Stable |
| Endolytic murein transglycosylase | 614 | 68,543.36 | 6.61 | 37 | 36 | 102.59 | 20.19 | 16,180 | − 0.226 | Stable |
| l-lactate dehydrogenase | 328 | 35,245.09 | 5.85 | 33 | 31 | 96.28 | 25.97 | 14,440 | − 0.089 | Stable |
| Ketol-acid reducto isomerase | 340 | 37,285.33 | 5.53 | 68 | 56 | 92.79 | 27.1 | 37,650 | − 0.277 | Stable |
| Aspartate-semialdehyde dehydrogenase | 358 | 38,903.31 | 6.21 | 45 | 41 | 89.54 | 29.85 | 23,452 | − 0.365 | Stable |
| Enolase | 432 | 46,857.61 | 9.32 | 56 | 92 | 87.62 | 38.9 | 47,655 | − 0.555 | Stable |
| UDP-N-acetylglucosamine 1-carboxyvinyl-transferase 1 | 423 | 45,616.65 | 4.95 | 45 | 33 | 92.46 | 34.55 | 11,564 | − 0.51 | Stable |
| ATP-dependent protease ClpE | 753 | 83,733.90 | 5.59 | 31 | 55 | 100.34 | 22.87 | 17,886 | − 0.195 | Stable |