Figure 5.

DFE inferences from subsets of C. elegans strains. (A, C) DFEs based on 273 “swept” strains with >30% of the genome showing strong influence of linked selection (Andersen et al. 2012). (B, D) DFEs based on 52 “divergent” strains with no evidence of selective sweeps across their genomes (see Methods). Panels (A) and (B) show inferences that used only zero- vs fourfold sites whereas C and D include sites designated as exerting high or moderate effects by SnpEff in the selected class. All estimated parameters of the inferred DFE are listed in Table  2. Error bars indicate 95% confidence intervals calculated from 5000 bootstrap replicates.