Table 1.

Comparison of four Plasmodium-specific recombinant pLDH proteins against their corresponding native counterparts related to their binding reactivity

	Recombinant protein				Clinical sample
Reactivity	PfLDH (n = 8)	PmLDH (n = 8)	PoLDH (n = 8)	PvLDH (n = 8)	P. falciparum (n = 29)	P. malariae (n = 15)	P. ovale (n = 4)	P. vivax (n = 58)
	Pan/Pf ratio			Pan/Pv ratio	Pan/Pf ratio			Pan/Pv ratio
Range	0.82–1.13	3.59–5.49	1.89–4.38	1.38–2.6	0.56 − 2.61	3.43–6.54	4.07–5.16	1.37–2.79
Mean	1.03	4.25	3.10	2.26	1.12	4.56	4.56	2.24
SD	0.1	0.78	1.04	0.38	0.55	1.0	0.46	0.37
t-test	–	–	–	–	P = 0.63	P = 0.33	P = 0.27	P = 0.89

Pan/Pf = PanLDH/PfLDH; Pan/Pv = PanLDH/PvLDH. Descriptive statistics for the ratio of PanLDH concentration to PfLDH or PvLDH concentration as indicated, determined via the 5-Plex. Any clinical samples that showed unquantifiable or infection-negative test results by the 5-Plex were excluded from analysis. P values correspond to comparison of different antigen sources.