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Overview of the association between mitochondrial homeostasis and NAFLD. Mitochondria are dynamic and complex organelles, and their homeostasis is mainly maintained by the balance of mitochondrial biogenesis, mitochondrial fission/fusion, and mitophagy. Mitochondrial injury can aggravate the hepatic lipid accumulation and ROS production and induce the inflammation and fibrosis that contribute to the pathogenesis and progression of NAFLD.
