FIGURE 2.

Natural products ameliorate NAFLD by regulating mitochondrial dysfunction. Mitochondrial dysfunction includes many aspects, such as the decreased ATP generation, mitochondrial biogenesis reduction, impaired mitophagy, imbalanced fission/fusion, and increased ROS production. The natural products, including phenols, alkaloids, flavonoids, isoflavones, and terpenoids, can significantly improve one or several aspects that linked to the mitochondrial dysfunction and subsequently improve the NAFLD.