Table 1.
General characteristics of ischemic stroke patients and healthy controls in discovery stage.
| IS (n = 150) | Control (n = 50) | p | |
|---|---|---|---|
| Age (years) | 60 (53–68) | 57 (55–66) | 0.696 |
| Sex (male, N, %) | 100 (66.7%) | 31 (62.0%) | 0.548 |
| HBP (N, %) | 100 (66.7%) | 20 (40.0%) | <0.001 |
| DM (N, %) | 47 (31.3%) | 4 (8.0%) | 0.001 |
| Hyperlipidemia (N, %) | 24 (16.0%) | 24 (48.0%) | <0.001 |
| CAD (N, %) | 28 (18.7%) | 9 (18.0%) | 0.916 |
| Smoking (N, %) | 74 (49.3%) | 14 (28.0%) | 0.008 |
| Drinking (N, %) | 59 (39.3%) | 10 (20.0%) | 0.013 |
| Admission NIHSS | 4 (2–7) | NA | NA |
| mRS at 3 months | 2 (1–3) | NA | NA |
| SBP (mmHg) | 142 (127–154) | 130 (120–139) | <0.001 |
| DBP (mmHg) | 83 (74–91) | 80 (72–85) | 0.074 |
| WBC (×109/L) | 6.6 (5.4–8.2) | 5.8 (4.9–6.9) | 0.016 |
| Platelet (×109/L) | 192.0 (148.0–225.8) | 205.0 (164.2–233.5) | 0.126 |
| BUN (mmol/L) | 5.0 (4.2–6.0) | 4.6 (4.0–6.2) | 0.784 |
| UA (μmol/L) | 337.0 (279.0–394.6) | 354.0 (289.4–434.4) | 0.191 |
| Creatinine (μmol/L) | 79.9 (68.0–89.0) | 74.2 (67.2–83.8) | 0.172 |
| eGFR (ml/min per 1.73 m2) | 84.9 (70.2–95.6) | 91.0 (76.8–98.7) | 0.231 |
| TG (mmol/L) | 1.6 (1.1–2.0) | 1.6 (1.3–2.4) | 0.374 |
| TC (mmol/L) | 4.1 (3.4–4.8) | 4.9 (4.2–5.5) | <0.001 |
| HDLC (mmol/L) | 1.02 (0.83–1.18) | 1.23 (0.99–1.40) | <0.001 |
| LDLC (mmol/L) | 2.4 (1.9–2.9) | 3.1 (2.6–3.6) | <0.001 |
| FBG (mmol/L) | 6.0 (5.1–7.8) | 5.1 (4.7–5.8) | 0.01 |
| HbA1c (%) | 6.0 (5.6–7.2) | 5.8 (5.5–6.0) | 0.114 |
| Homocysteine (μmol/L) | 13.4 (11.2–17.4) | 12.8 (10.5–13.6) | 0.042 |
IS, ischemic stroke; HBP, hypertension; DM, Diabetes mellitus; CAD, coronary artery disease; NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin Scale; SBP, systolic blood pressure, DBP, diastolic blood pressure; WBC, white blood cell; BUN, blood urea nitrogen; UA, uric acid; eGFR, estimated glomerular filtration rate; TG, triglyceride; TC, total cholesterol; HDLC, high density lipoprotein cholesterol; LDLC, low density lipoprotein cholesterol; FBG, fasting blood glucose; HbA1c, glycosylated hemoglobin A1c.