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. 2021 Dec 23;12:782767. doi: 10.3389/fphys.2021.782767

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Copyright © 2021 Zhou, Singh, Monnier, Marszalec, Gao, Jin, Frisk, Louch, Verma, Krishnamurthy, Nico, Mulla, Aistrup, Kishore and Wasserstrom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed model of BIN1 in T-tubule formation. (A) Crystal structure of N-BAR of BIN1 (PDB ID: 2FIC) consists of a coiled-coil domain. The short loop segment between helix 2 and 3 has three lysine residues from amino acid 164 to 166 (red). (B) Two BIN1 N-BARs (one in green color and the other in orange color) form a “banana”-shaped curve through their lateral interactions. (C) In T-tubule formation, BIN1 N-BAR domain oligomerizes to form a patterned lattice (modeled based on F-BAR domain) around the lipid bilayer.