Lee 1995.

Methods	Single‐centre randomised control trial
Participants	Inborn and outborn infants with a birth weight < 1500 g
Interventions	One group of infants (unwashed RBC group) were randomised to receive type‐specific packed RBCs from dedicated donor (either community or directed donation) units equipped with 7 satellite bags. The other group of infants (washed RBC group) received packed RBCs from units divided into 3 split packs shared with other infants receiving transfusions
Outcomes	The primary outcome of the study was number of donor exposures per infant
Notes	Infants were monitored until 1‐hour post‐transfusion for acute transfusion reactions. Data regarding demographics, length of hospital stay, days of mechanical ventilation, days of supplemental oxygen use, and RBC transfusion details were collected
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Low risk	Study infants were randomly assigned by hospital blood bank personnel into 1 of 2 groups
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Transfusions were ordered by primary caretakers who were masked to study group assignments. RBCs were processed by hospital blood bank personnel and sent to the neonatal intensive care unit in syringes unmarked as to study group assignment
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Low risk for mortality; unclear risk for other outcomes
Incomplete outcome data (attrition bias) All outcomes	Low risk	Two infants withdrew from the study after randomisation, but this level of missing data is unlikely to affect observed results
Selective reporting (reporting bias)	Unclear risk	No published study protocol was available to review
Other bias	Low risk	No other risks of bias were identified

RBC: red blood cell