TABLE 1.
Reactive oxygen species-regulating biomaterials for tissue regeneration applications.
| Bioactive cue/scaffold | Animal model | Key findings | References |
|---|---|---|---|
| Rapamycin-loaded scaffolds | Intervertebral disk | Macrophages polarization toward M2 phenotypes increased while ROS level decreased | Bai et al. (2020) |
| ROS-cleavable polymers, catalase, 4-amino-TEMPO based HA hydrogels | Myocardial infarction | ROS level and infarct size decreased while cell viability, cardiac function and angiogenesis increased | Ding et al. (2020), Wang et al. (2019), Zhu et al. (2018) |
| Nitric oxide releasing poly (arginine) hydrogels | Nitric oxide release and angiogenesis increased while ROS level and infarct size decreased | Vong et al. (2018) | |
| Curcumin-loaded poly (propylene sulphide) nanoparticles | Hind-limb ischemia or reperfusion | ROS level, oxidative stress, and cell apoptosis decreased while limb regeneration increased | Poole et al. (2015) |
| Ascorbic acid loaded polyurethane | Oxidative stress and cell apoptosis decreased | Shiekh et al. (2018) | |
| FGF-2-loaded cardiac patch | FGF-2 release and neo-myogenesis increased while cardiac fibrosis decreased | Li Z. et al. (2021) | |
| ROS-scavenging PLGA hydrogels | Bone/cartilage | Inflammation decreased while glycosaminoglycans and collagen increased | Wu et al. (2021) |
| BMP-2-loaded PTK-based coatings | BMP-2 delivery and bone regeneration increased | Martin et al. (2021) | |
| PEA-PAA hydrogels | Skin injury | Cell growth, cell viability, wound healing, and arginine release increased | Zhang J. et al. (2021) |
| Mupirocin and GM-CSF-loaded PVA scaffolds | ROS level decreased while M2 macrophages and wound healing increased | Zhao et al. (2020) | |
| Tannic acid, curcumin or Spirulina extract loaded chitin hydrogels or PCL nanofibers | Antibacterial activity, wound healing, angiogenesis, and anti-inflammatory activity increased while oxidative stress decreased | Jung et al. (2016), He et al. (2020), Ma et al. (2020), Yang et al. (2021) | |
| Gallic acid loaded hydrogels or sutures | Oxidative damage decreased while cell viability, neovascularization, and wound repair increased | Le Thi et al. (2020), Zhu et al. (2021) | |
| EGF-loaded PEG hydrogels | ROS level and scar formation decreased while EGF release and skin repair increased | An et al. (2022) | |
| MnO2-loaded HA hydrogels | ROS level decreased while oxygen release and angiogenesis increased | Xiong et al. (2021) | |
| Curcumin and Zn2+-loaded PLLA scaffolds | ROS level and inflammatory response decreased while Zn2+ and epithelialization increased | Wang Y. et al. (2020) | |
| PNA nanogel-loaded PLLA nanofibers | Cell adhesion and proliferation increased while ROS level decreased | Zhang J. et al. (2021) | |
| Ce6, Mg2+, and EGCG loaded chitosan NPs | Mg2+ release, skin repair, and antibacterial activity increased while ROS level decreased | Hu et al. (2019) | |
| SDF-1α-loaded PPADT | SDF-1α release, skin repair, and BMSCs homing increased | Tang et al. (2015) | |
| Clindamycin-loaded PVA microneedle patch | Bacterial growth decreased while drug penetration increased | Zhang et al. (2018) | |
| Ceria-loaded PCL scaffold | In vitro studies | ROS level and cardiac hypertrophy decreased | Jain et al. (2021) |
| H2S-releasing scaffolds | H2S, cell survival and proliferation increased | Feng et al. (2015) |
EGF, epidermal growth factor; PLLA, poly(l-lactic acid); EGCG, epigallocatechin-3-gallate.