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. 2021 Dec 23;9:802279. doi: 10.3389/fchem.2021.802279

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Copyright © 2021 Deng, Li, Luo, Zheng, Chen, Zhang, Zhang, Zhou and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of disruptions of the mshA and mst genes on the production of granaticins. (A) HPLC profiling of the Streptomyces vietnamensis wild type and genetically manipulated strains. Note that granaticin MA (3) might be a degradation product of mycothiogranaticin A (1) and could not be detected in the fermentation broth under the standard procedures. (B) The supernatants and diluted supernatants of the S. vietnamensis strains in different media. WT-Y, ΔmshA-Y, ΔmshA::mshA-Y, Δmst-Y, WT-G, ΔmshA-G, ΔmshA::mshA-G and Δmst-G stand for the wild-type (WT), mutant ΔmshA, complementary strain ΔmshA::mshA and mutant Δmst in the YEME (Y) or Gauze’s synthetic No.1 (G) media, respectively. Tris-EDTA buffer (pH 8.0) was used for dilution. (C) The overall yields of granaticins and biomass of the wild type, mutant and complementary strains.