Comparison 3. Heated tobacco product (HTP) use compared with snus use.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Adverse events	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3.2 Serious adverse events	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3.3 1‐Hydroxypyrene (1‐OHP)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.4 1‐Naphthol	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.5 2‐Naphthol	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.6 Carboxyhaemoglobin (COHb)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.7 3‐Hydroxypropylmercapturic acid (3‐HPMA)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.8 Monohydroxy‐3‐butenyl mercapturic acid (MHBMA)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3.9 4‐(Methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected