Table 2. Clinical Course.
| Variable | No. (%) |
|---|---|
| Site of initial presentation | |
| Inpatient (developed while already admitted) | 178 (52.4) |
| Outpatient | |
| Dermatology | 28 (8.2) |
| Other | 28 (8.2) |
| Emergency department | 94 (27.6) |
| Other/not specified | 12 (3.5) |
| Suspected cause of AGEP | |
| Medication | 291 (85.6) |
| Single potential agent | 180 (61.9) |
| Multiple potential agents | 111 (32.6) |
| Infection | 3 (0.9) |
| Intravenous contrast agent | 7 (2.1) |
| Other/unknown | 39 (11.5) |
| Mucosal involvementa | 20 (5.9) |
| Ocular | 0 |
| Oral | 18 (90.0) |
| Nasal | 1 (5.0) |
| Genital | 3 (15.0) |
| Biopsy performed | 245 (72.1) |
| Both papillary edema and spongiform subcorneal and/or intraepidermal pustules | 50 (20.4) |
| Either papillary edema with any kind of pustule other than spongiform or spongiform subcorneal and/or intraepidermal pustules | 167 (68.2) |
| Only exocytosis of polymorphonuclear neutrophils | 4 (1.6) |
| Other | 24 (9.8) |
| Fever (temperature ≥38.0 °C) | 154/310 (49.7) |
| Fever duration, median (IQR) [range], d | 2 (1 to 4) [0 to 21] |
| Start of fever relative to AGEP start date, median (IQR) [range], d | 1 (0 to 3) [−8 to 11] |
| Fever temperature, median (IQR) [range], °C | 38.8 (38.3 to 39.4) [38.0 to 40.6] |
| Elevated PMNs | 263/309 (85.1) |
| Eosinophilia | 161/309 (52.1) |
| Elevated WBC count | 270/289 (93.4) |
| Hypocalcemia | 207/315 (65.7) |
| Acute transaminitis (uncorrected) | 60/298 (20.1) |
| Baseline AST/ALT values available | 34/60 (56.7) |
| Acute transaminitis after considering baseline AST/ALT values | 25/34 (73.5) |
| Corrected frequency of acute transaminitis | 25/298 (8.4) |
| Days to peak AST/ALT values relative to AGEP start date, median (IQR) | 6 (3-9) |
| No. with creatinine measured during AGEP course | 319 (93.8) |
| No. with baseline creatinine in 7 d prior to AGEP | 86/319 (27.0) |
| No. with AKI | 25/86 (29.1) |
| Prevalence of AKI | 25/319 (7.8) |
| AKI relative to AGEP start date, median (IQR) | 4 (2-5) |
Abbreviations: AGEP, acute generalized exanthematous pustulosis; AKI, acute kidney insufficiency; ALT, alanine aminotransferase; AST, aspartate aminotransferase; PMN, polymorphonuclear neutrophils; WBC, white blood cell.
a
All types of mucosal involvement for each patient were included.