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Mechanism of action of CDK4/6 inhibitors in CRC cells. Palbociclib, Ademaciclib, Ribociclib, CINK4 and Trilaciclib are able to prevent the formation of Cyclin D/CDK4/6 complexes, which reduces Retinoblastoma phosphorylation and induces G1 cell cycle arrest. Palbociclib has been shown to be effective in promoting p53 transcription after irradiation as well.
