Table 4.
Multivariate regression analysis of risk factors for cardiac surgery-associated acute kidney injury
| OR (95% CI) | P value | Hosmer-Lemeshow test (P value) | |
| Model 1* | 0.433 | ||
| Male | 1.797 (1.378 to 2.344) | <0.001 | |
| Age | 1.026 (1.014 to 1.038) | <0.001 | |
| Diabetes | 1.681 (1.188 to 2.378) | 0.003 | |
| NYHA grade >II | 1.120 (1.064 to 1.437) | 0.023 | |
| Preoperative eGFR (<60 mL/(min/1.73m2)) | 1.668 (1.071 to 2.598) | 0.024 | |
| High-risk surgery | 1.749 (1.117 to 2.380) | <0.001 | |
| Extracorporeal circulation time | 1.046 (1.012 to 2.362) | <0.001 | |
| Hyperuricaemia | 1.237 (1.095 to 1.885) | 0.009 | |
| Model 2 (model 1+overweight×hyperlipidaemia)† | 0.638 | ||
| Male | 1.892 (1.415 to 2.531) | <0.001 | |
| Age | 1.032 (1.019 to 1.046) | <0.001 | |
| Diabetes | 1.490 (1.002 to 2.215) | 0.047 | |
| Preoperative eGFR (<60 mL/(min/1.73m2)) | 1.741 (1.150 to 2.635) | 0.029 | |
| High-risk surgery | 1.698 (1.134 to 2.459) | 0.013 | |
| Extracorporeal circulation time | 1.009 (1.006 to 1.013) | <0.001 | |
| Overweight×hyperlipidaemia | 1.544 (1.059 to 2.252) | 0.024 | |
| Model 3 (model 1+hyperuricaemia×overweight×hyperlipidaemia)‡ | 0.597 | ||
| Male | 1.658 (1.303 to 2.110) | <0.001 | |
| Age | 1.029 (1.017 to 1.040) | <0.001 | |
| Preoperative eGFR (<60 mL/(min/1.73 m2)) | 1.739 (1.165 to 2.595) | 0.007 | |
| High-risk surgery | 1.779 (1.128 to 2.673) | 0.017 | |
| Extracorporeal circulation time | 1.011 (1.007 to 1.015) | <0.001 | |
| Hyperuricaemia×overweight×hyperlipidaemia | 3.126 (1.731 to 5.646) | <0.001 |
*Covariates adjusted for in model A: male, age, overweight, diabetes, angiography, NYHA grade >II, preoperative eGFR <60 mL/(min/1.73 m2), high-risk surgery, extracorporeal CPB time and aortic occlusion time.
†Covariates adjusted for in model B: male, age, overweight, diabetes, angiography, NYHA grade >II, preoperative eGFR <60 mL/(min/1.73 m2), high-risk surgery, extracorporeal CPB time and aortic occlusion time.
‡Covariates adjusted for in model C: male, age, overweight, diabetes, angiography, NYHA grade >II, preoperative eGFR <60 mL/(min/1.73 m2), high-risk surgery, extracorporeal CPB time and aortic occlusion time.
CPB, cardiopulmonary bypass; eGFR, estimated glomerular filtration rate; NYHA, New York Heart Association.