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. 2022 Jan 6;23:9. doi: 10.1186/s13059-021-02572-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Illustration of full-stack modeling annotations. The figure illustrates the full-stack modeling at two loci. The top track shows chromatin state annotations from the full-stack modeling colored based on the legend at right. Below it are signal tracks for a subset of the 1032 input datasets. Data from seven (DNase I hypersensitivity, H3K27me3, H3K36me3, H3K4me1, H3K4me2, H3K4me3, and H3K9me3) of the 32 chromatin marks are shown, colored based on the legend at right. These data are from 15 of the 127 reference epigenomes each representing different cell and tissue groups. The loci on left highlight a genomic region for which a portion is annotated as constitutive promoter states (TSS1-2). The loci on the right panel highlight a region for which a portion is annotated as a brain enhancer state (EnhA6), which has high signals of H3K27ac in reference epigenomes of the group Brain. The concatenated model annotations for these loci from these and additional reference epigenomes can be found in Additional File 1: Fig. S24