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. 2021 Dec 23;27:1610013. doi: 10.3389/pore.2021.1610013

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Copyright © 2021 Kobayashi, Kitazono, Akahane, Yanazume, Kamio, Togami, Nohara, Sakamoto, Yokoyama, Tabata, Kobayashi and Tanimoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Values of MSI and TMB in endometrial cancers. (A) The MSI (left panel) and TMB (right panel) scores of MMR-d EC cases are significantly higher than those of EC cases that are MMR-p. (B) The MSI and TMB scores of endometrial cancers are plotted as a scattergram, showing clear distinction of MMR-p (blue dot) and MMR-d cases (red dot), and TMB-ultrahigh POLE mutation cases (green dot). MMR, mismatch repair; MSI, microsatellite instability; TMB, tumor mutation burden; MMR-p, mismatch repair-proficient; MMR-d, mismatch repair-deficient.