Vardy 2009.

Study name	Evaluation of a web‐based cognitive rehabilitation programme in cancer survivors with self reported cognitive impairment
Methods	RCT
Participants	Inclusion criteria Diagnosis of a primary breast, colorectal or ovarian cancer with completion of a minimum of 3 cycles of potentially curative chemotherapy within the last 6 to 60 months (completion of radio‐ or immuno‐ therapy 12 weeks prior to study enrolment), hormonal therapy is permitted if commenced at least 4 weeks prior to randomisation, aged 18 years or older, male or female, self‐reporting changes in memory and concentration, English language fluency, able to give informed consent, access to computer and Internet and available for intervention and follow‐up. Exclusion criteria ECOG Performance Status of > 2, evidence of recurrent or metastatic disease, history of, or active psychiatric, cognitive or neurological or other disorder which may impact on cognitive testing, psychotropic medication use is permitted if a stable routine has been established, any previous chemotherapy or cancer (with the exception of non‐melanoma skin cancer, cervical cancer in situ).
Interventions	Definition: Computerised cognitive training and 30‐minute telephone consultation teaching compensatory strategies Materials: Computer, Internet access Duration: Four‐weekly 45‐minute sessions per week for a total of 15 weeks Setting: Home Comparator: Treatment as usual (30‐minute telephone consultation teaching compensatory strategies)
Outcomes	Assessments taken at baseline, post‐intervention and 6 months post‐intervention Primary outcome Self‐reported cognitive function as assessed by the Functional Assessment of Cancer Therapy ‐ Cognitive Function (FACT‐COG). Secondary outcomes Objective cognitive function as assessed by the CogState battery of tests (memory, attention and decision making). Depression/Anxiety as assessed by the General Health Questionnaire (GHQ); Fatigue as assessed by FACT‐F; QoL as assessed by the FACT‐G and; Stress as assessed by the PSS
Starting date	Trial closed‐ data not yet available
Contact information	Victoria Bray: victoria.bray2@sswhas.nsw.gov.au
Notes

Abbreviations: ADD = Attention Deficit Disorder; BPNS = basic Psychological Needs Survey; BVMT = Brief Visuospatial Memory Test; CD = Compact Disc; CNS = Central Nervous System; COWAT = Controlled Oral Word Association Test; ECOG = Eastern Cooperative Oncology Group; EEG = electroencephalogram; EORTC‐CF = European Organisation for Research and Treatment for Cancer‐ Cognitive Function subscale; EORTC‐QLQ‐C30 = European Organisation for Research and Treatment for Cancer‐ Quality of Life Questionnaire; FACT‐Cog = Functional Assessment of Cancer Therapy‐ Cognition subscale; FACT‐F = Functional Assessment of Cancer Therapy‐Fatigue subscale; FACT‐G = Functional Assessment of Cancer Therapy‐General scale; fMRI = functional Magnetic Resonance Imaging; HADS = Hospital Anxiety Depression Scale; HVLT‐R = Hopkin's Verbal Learning Test‐ Revised; MMSE = Mini‐Mental Status Examination; PSS = Perceived Stress Scale; PHQ = Patient Health Questionnaire; POMS = Profile of Mood State; QoL = quality of life; RCT = Randomised Controlled Trial; SD = Standard Deviation; WAIS = Wechsler Adult Intelligence; WCST = Wisconsin Card Sorting Test; WFT = Word Fluency Test; WRAT = Wide Range Achievement Test