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. 2022 Jan 6;15:2. doi: 10.1186/s13072-021-00433-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Gains and losses of select histone posttranslational modifications during epididymal maturation of mouse sperm. A Heatmap comparing the LC/MS-derived percentages for each peptide transition as a fraction of the total peptide pool (all modifications + unmodified peptides = 100%). Data represent the average of three independent runs obtained from a pooled sample of 10 million caput and cauda sperm. B–M Bar graphs contrasting gains and losses of unmodified (UN) histones with the levels of lysine acetylation (AC), monomethylation (ME1) dimethylation (ME2), and trimethylation (ME3) in sperm isolated from the caput and caudal portions of the epididymis. Error bars represent the SEM, n = 3 replicates, ** p < 0.01, *** p < 0.001, **** p < 0.0001