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. 2022 Jan 6;15:2. doi: 10.1186/s13072-021-00433-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — During epididymal maturation, broad H3K27ac peaks sharpen and transition from intronic and distal regions to gene promoters and enhancers driving embryo development. A Correlation analysis between H3K27ac ChIP-seq signals derived from sperm isolated from the caput and cauda regions of the epididymis (n = 2). Venn diagrams comparing changes in B broad and C narrow H3K27ac peaks between caput and cauda-derived sperm. D Integrative Genome Viewer tracks of chromosomal regions exhibiting the transition from diffuse broad peaks to more focused enrichment between caput and cauda-derived sperm. Bar chart representation of the distribution of H3K27ac across key genomic features between E caput and F cauda-derived samples. Heatmaps displaying the enrichment of H3K27ac signals across G CpG islands, H transcriptional start sites, or I regions with a proximal enhancer-like signature