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. 2022 Jan 6;15:2. doi: 10.1186/s13072-021-00433-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Broad domains of H3K27ac in caudal sperm overlap with broad domains of H3K4me3 in MII Oocytes and colocalize to regions of open chromatin identified in the ATAC-seq profiles of MII oocytes and sperm. Venn diagrams comparing broad domains of H3K27ac identified in caudal sperm to broad domains of H3K27ac (A) and H3K4me3 (B) previously identified in MII oocytes (dataset GSE72784, [39]). Overlapping H3K27ac-H3K27ac (C) and H3K4me3-H3K27 (D) regions predominantly map to within 1 kb of gene promoters. E Correlation analysis between H3K9me2 and H3K27ac-enriched regions in caput and caudal sperm with regions of open chromatin identified using ATAC-seq in MII oocytes and sperm (GSE116854 [38]). Heatmaps showing the localization of broad (F) and narrow (G) H3K27ac peaks in caudal sperm at ATAC-seq Tn5-hypersensitive sites sperm and MII oocytes