Figure 6: Direct from patient in vitro screening recapitulates findings from PDX screen.

(A) Dose response curve of drugs tested in triplicate against cells dissociated directly from patient tumors (T6-T11) versus PHH. Error bars – standard deviation. Drugs were tested at 10μM-10nM with 2-fold serial dilution. The y-axis shows normalized percent survival calculated as 100 –[(positive control–drug response)/(positive control-negative control)*100]. Cells were treated for 72h, and normalized percent survival was quantified using Cell Titer Glo. (B) Comparison of the EC₅₀ in cells dissociated from patient tumor FLC.T6 vs cells dissociated from its derived PDX FLC6.