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. 2022 Jan 6;41:12. doi: 10.1186/s13046-021-02215-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Overview of ongoing and completed clinical trials with CD70-targeting agents. Completed trials (solid line) and ongoing trials (dashed line) were sorted based on study start date. Antibody-drug conjugates (ADC, blue); Antibody (Ab, Red); Chimeric antigen receptor (CAR, Green). Efficacy data are depicted when available. Abbreviations: ADC, antibody drug conjugate: Ab, antibody; CAR, chimeric antigen receptor; CR, complete remission; PR, partial remission; SD, stable disease; CRi, CR with incomplete hematological recovery; NHL, non-Hodgkin lymphoma; CTCL, cutaneous T cell lymphoma; RCC, renal cell carcinoma; NPC, nasopharynx carcinoma; AML, acute myeloid leukemia; MDS, myelodysplastic syndrome; BCL, B cell lymphoma; MM, multiple myeloma; TCL, T cell lymphoma; Pt, patients; Exp, expected