Table 3.
Uric acid risk allele frequencies comparisons Asian and Native Hawaiian and Pacific Islanders Subgroups
| Gene (SNP) | Variant Type | Allele | EUR† % (n) | Filipino % (n) | Korean % (n) | Japanese % (n) | Native Hawaiian % (n) | Marshallese % (n) | Samoan % (n) | Gout/ Urate Effect (↑↓) |
|---|---|---|---|---|---|---|---|---|---|---|
|
ABCG2 (rs2231142 G > T) |
Missense |
G T |
90.6 (911) 9.4 (95) |
54.2 (194)* 45.8 (164) |
72.2 (133)* 27.8 (51) |
74.4 (278) * 25.6 (96) |
87.3 (253) 12.7(37) |
82.4 (201)* 17.6 (43) |
68.9 (251)* 31.1 (113) |
↑ |
|
SLC2A9 (rs734553 G > T) |
Intronic |
G T |
24.5 (246) 75.5 (760) |
1.2 (4)* 98.8 (348) |
1.7 (3)* 98.3 (183) |
0.5 (2)* 99.5 (368) |
9.1 (26)* 90.9 (260) |
0.0 (0)* 100.0 (242) |
1.7 (6)* 98.3 (358) |
↑ |
|
SLC17A1 (rs1183201T > A) |
Intronic |
A T |
46.1 (464) 53.9 (542) |
20.9 (73) * 79.1 (277) |
14.6 (26)* 85.4 (152) |
17.1 (63)* 82.9 (305) |
34.0 (98)* 66.0 (190) |
57.2 (135)* 42.8 (101) |
28.4(103)* 71.6 (259) |
↓ |
|
SLC16A9 (s2242206 G > T) |
Missense |
G T |
73.4 (738) 26.6 (268) |
55.0 (197)* 45.0 (161) |
40.8 (75) * 59.2 (109) |
44.5 (163)* 55.5 (203) |
54.9(158)* 45.1 (130) |
55.5 (132)* 44.5 (238) |
60.7(221)* 39.3 (143) |
↓ |
|
GCKR (rs780094 C > T) |
Intronic |
C T |
58.9 (593) 41.1 (413) |
55.1 (197) 44.9 (161) |
58.2 (107) 41.8 (77) |
42.0 (156) * 58.0 (216) |
65.9 (190) 34.1 (98) |
64.5 (156) 35.5 (86) |
69.4(254)* 30.6 (112) |
↑ |
| SLC22A11 (rs17300741G > A) | Intronic |
A G |
46.2 (465) 53.8 (541) |
85.3 (297)* 14.7 (51) |
89.6 (163)* 10.4 (19) |
84.7(305) * 15.3 (55) |
72.3 (201) * 27.7 (77) |
70.0 (167) * 30.0 (73) |
78.5 (281)* 21.5 (77) |
↑ |
|
SLC22A12 (rs505802 C > T) |
Intergenic |
T C |
70.7 (711) 29.3 (295) |
21.6 (79)* 78.4 (287) |
20.4 (38)* 79.6 (148) |
18.3 (68)* 81.7 (304) |
37.6 (109)* 62.4 (181) |
5.0 (12) * 95.0 (230) |
31.5(116)* 68.5 (252) |
↓ |
| LRRC16A (rs742132 G > A) | Intronic |
A G |
69.0 (694) 31.0 (312) |
69.7 (251) 30.3 (109) |
78.0 (142) 22.0 (40) |
78.2 (291)* 21.8 (81) |
58.6 (171)* 41.4 (121) |
70.0 (168) 30.0 (72) |
51.7 (188)* 48.3 (176) |
↑ |
|
PDZK1** (rs12129861 C > T) |
Intergenic |
C T |
54.1 (544) 45.9 (462) |
44.7 (151)* 55.3 (187) |
56.8 (92) 43.2 (70) |
48.9 (178) 51.1 (186) |
39.3 (106)* 60.7 (164) |
39.5 (90)* 60.5 (138) |
46.5 (159)* 53.5 (183) |
↓ |
The bolded letter refers to the risk allele linked to hyperuricemia or gout
*Indicates statistical significance p < 0.006 between the subgroups and the comparator group (EUR)
†Data from the 1000 Genomes Project Phase III
**Allele deviated from HWE in all study subgroups