Table 4.
Uric acid Genotype frequencies comparisons Asian, Native Hawaiian, and Pacific Islanders Subgroups
| Gene (SNP) | Genotype | EUR† % (n) | Filipino % (n) | Korean % (n) | Japanese % (n) | Native Hawaiian % (n) | Marshallese % (n) | Samoan % (n) |
|---|---|---|---|---|---|---|---|---|
|
ABCG2 (rs2231142 G > T) |
GG GT TT |
82.3 (414) 16.5 (83) 1.2 (6) |
28.4 (51) 51.4 (92) 20.1 (36) |
56.5 (52) 31.5 (29) 12.0 (11) |
56.7 (106) 35.3 (66) 8.0 (15) |
75.5 (110) 23.1 (33) 1.4 (2) |
68.0 (83) 28.7 (35) 3.3 (4) |
48.9 (89) 40.1 (73) 11 (20) |
|
SLC2A9 (rs734553 G > T) |
GG GT TT |
5.6 (28) 37.8 (190) 56.6 (285) |
– 2.3 (4) 97.7 (172) |
– 3.2 (3) 96.8 (90) |
– 1.1 (2) 98.9 (183) |
1.4 (2) 15.4 (22) 83.2 (119) |
– – 100 (121) |
– 3.3 (6) 96.7 (176) |
|
SLC17A1 (rs1183201 T > A) |
AA AT TT |
23.1 (116) 46.1 (232) 30.8 (155) |
4.0 (7) 33.7 (59) 62.3 (109) |
1.1 (1) 27.0 (24) 71.9 (64) |
3.8 (7) 26.6 (49) 69.6 (128) |
11.8 (17) 44.4 (64) 43.8 (63) |
29.7 (35) 55.0 (65) 15.3 (18) |
6.6 (12) 43.7 (79) 49.7 (90) |
| SLC16A9 (rs2242206 G > T) |
GG CT TT |
54.9 (276) 37.0 (186) 8.1 (41) |
32.9 (59) 44.1 (79) 23.0 (41) |
15.2 (14) 51.1 (47) 33.7 (31) |
16.9 (31) 55.2 (101) 27.9 (51) |
34.7 (50) 40.3 (58) 25.0 (36) |
31.9 (38) 47.1 (56) 21.0 (25) |
33.0 (60) 55.5 (101) 11.5 (21) |
|
GCKR (rs780094 C > T) |
CC CT TT |
33.6 (169) 50.7 (255) 15.7 (79) |
31.8 (57) 46.4 (83) 21.8 (39) |
35.9 (33) 44.6 (41) 19.5 (18) |
18.8 (35) 46.3 (86) 34.9 (65) |
41.7 (60) 48.6 (70) 9.7 (14) |
41.3 (50) 46.3 (56) 12.4 (15) |
48.1 (88) 42.6 (78) 9.3 (17) |
|
SLC22A11 (rs17300741G > A) |
AA AG GG |
23.5 (118) 45.5 (229) 31.0 (156) |
73.6 (128) 23.5 (41) 2.9 (5) |
80.2 (73) 18.7 (17) 1.1 (1) |
71.7 (129) 26.1 (47) 2.2 (4) |
54.0 (75) 36.7 (51) 9.3 (13) |
53.3 (64) 32.5 (39) 14.2 (17) |
62.6 (112) 31.8 (57) 5.6 (10) |
|
SLC22A12 (rs505802 C > T) |
CC CT TT |
9.9 (50) 38.8 (195) 51.3 (258) |
61.2 (112) 34.4 (63) 4.4 (8) |
63.4 (59) 32.3 (30) 4.3 (4) |
67.7 (126) 28.0 (52) 4.3 (8) |
35.8 (52) 53.1 (77) 11.1 (16) |
90.9 (110) 8.3 (10) 0.8 (1) |
48.9 (90) 39.1 (72) 12.0 (22) |
| LRRC16A (rs742132 G > A) |
AA AG GG |
48.3 (243) 41.4 (208) 10.3 (52) |
48.9 (88) 41.7 (75) 9.4 (17) |
60.4 (55) 35.2 (32) 4.4 (4) |
62.4 (116) 31.7 (59) 5.9 (11) |
30.2 (44) 56.8 (83) 13.0 (19) |
51.7 (62) 36.7 (44) 11.6 (14) |
25.2 (46) 52.8 (96) 22.0 (40) |
|
PDZK1** (rs12129861 C > T) |
CC CT TT |
30.4 (153) 47.3 (238) 22.3 (112) |
42 (71) 5.4 (9) 52.6 (89) |
54.3 (44) 4.9 (4) 40.8 (33) |
47.8 (87) 2.2 (4) 50.0 (91) |
36.3 (49) 5.9 (8) 57.8 (78) |
37.7 (43) 3.5 (4) 58.8 (67) |
42.2 (72) 8.7 (15) 49.1 (84) |
The bolded letter refers to the risk allele linked to hyperuricemia or gout
†Data from the 1000 Genomes Project Phase III
**Allele deviated from HWE in all study subgroups