Table 3.
Association of baseline hs-CRP and longitudinal hs-CRP changes with incident MetS among age, sex and BMI subgroups (N = 4,116)
| Subgroups | Quartiles of hs-CRP at baseline | P for interactiona | Groups of absolute changes in hs-CRP during the follow–up | P for interactiona | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Group 1 | Group 2 | Group 3 | Group 4 | |||
| Age | 0.41 | 0.66 | ||||||||
| 45–60 years | ||||||||||
| Case/total | 50/692 | 83/630 | 83/597 | 103/560 | 76/862 | 52/545 | 81/543 | 110/529 | ||
| OR (95% CI)b | 1.00 (Ref.) | 1.70 (1.16, 2.53) | 1.64 (1.11, 2.44) | 2.03 (1.39, 3.00) | 1.00 (Ref.) | 1.62 (1.05, 2.49) | 2.65 (1.78, 3.95) | 3.63 (2.52, 5.27) | ||
| > 60 years | ||||||||||
| Case/total | 30/335 | 47/389 | 61/442 | 78/471 | 64/617 | 25/328 | 52/325 | 75/367 | ||
| OR (95% CI)b | 1.00 (Ref.) | 1.26 (0.77, 2.1) | 1.29 (0.80, 2.11) | 1.57 (0.99, 2.54) | 1.00 (Ref.) | 0.97 (0.56, 1.66) | 2.27 (1.43, 3.6) | 2.92 (1.93, 4.47) | ||
| Sex | 0.66 | 0.68 | ||||||||
| Male | ||||||||||
| Case/total | 34/437 | 54/453 | 57/509 | 78/530 | 59/727 | 26/398 | 55/366 | 83/438 | ||
| OR (95% CI)b | 1.00 (Ref.) | 1.50 (0.94, 2.44) | 1.25 (0.78, 2.03) | 1.80 (1.15, 2.86) | 1.00 (Ref.) | 0.94 (0.54, 1.61) | 2.52 (1.59, 4.01) | 3.64 (2.42, 5.54) | ||
| Female | ||||||||||
| Case/total | 46/590 | 76/566 | 87/530 | 103/501 | 81/752 | 51/475 | 78/502 | 102/458 | ||
| OR (95% CI)b | 1.00 (Ref.) | 1.55 (1.04, 2.33) | 1.70 (1.15, 2.55) | 1.90 (1.28, 2.84) | 1.00 (Ref.) | 1.70 (1.10, 2.63) | 2.60 (1.75, 3.90) | 3.3 (2.28, 4.83) | ||
| BMI | 0.69 | 0.40 | ||||||||
| BMI < 24.0 kg/m2 | ||||||||||
| Case/total | 44/817 | 56/722 | 56/705 | 73/655 | 53/1,035 | 31/638 | 62/608 | 83/618 | ||
| OR (95% CI)b | 1.00 (Ref.) | 1.47 (0.97, 2.24) | 1.38 (0.91, 2.11) | 2.05 (1.38, 3.07) | 1.00 (Ref.) | 1.46 (0.88, 2.42) | 3.23 (2.09, 5.05) | 4.08 (2.73, 6.18) | ||
| BMI ≥ 24.0 kg/m2 | ||||||||||
| Case/total | 36/210 | 74/297 | 88/334 | 108/376 | 87/444 | 46/235 | 71/260 | 102/278 | ||
| OR (95% CI)b | 1.00 (Ref.) | 1.61 (1.02, 2.57) | 1.64 (1.05, 2.60) | 1.79 (1.16, 2.80) | 1.00 (Ref.) | 1.3 (0.83, 2.02) | 2.09 (1.39, 3.15) | 2.85 (1.96, 4.17) | ||
BMI, body mass index; CI, confidence interval; hs-CRP, high-sensetive C reactive protein; MetS, metabolic syndrome; OR, odds ratio
aP values for interaction were estimated using the likelihood ratio test for the product term of the stratifying variables and hs-CRP groups to the main model
bAll models were adjusted for age (continuous, years), sex (male and female), education level (illiterate, primary school, middle school, and high school or above), and residence (urban and rural), cigarette smoking (never, former, and current), alcohol drinking (never, former, and current), BMI (continuous, kg/m2), hypertension (yes and no), dyslipidemia (yes and no), diabetes (yes and no), heart disease (yes and no) and stroke (yes and no)