Table 4.

Performance evaluation of three methods overall and among the study Plasmodium falciparum cases, from December 2019 to March 2020, Ethiopia

Characteristics	Sensitivity (CI 95%)	Specificity (CI 95%)	PPV (CI 95%)	NPV (CI 95%)
Multiplex real-time PCR vs microscopy
Overall	100 (93–100)	83.2 (77.6–87.9)	57.9 (47–68.4)	100 (98–100)
P. falciparum	100 (89–100)	83.6 (78- 88)	45.83 (34–58)	100 (98.2–100)
RDT vs microscopy
Overall	98 (89.6–99.9)	95 (91–97.5)	82 (70–0.6)	99.5 (97–100)
P. falciparum	100 (89–100)	95.4 (91.9–7.7)	75 (59.7–86.8)	100 (98.4–100)
Microscopy vs multiplex real-time PCR
Overall	58 (46.9–68.4)	100 (98–100)	100 (93–100)	83.2 (77.6–87.9)
P. falciparum	45.8 (34–58)	100 (98.2–100)	100 (89–100)	83.6 (78.3–88.1)
RDT vs multiplex real-time PCR
Overall	67 (56.21–76.7)	98.9 (96–99.9)	96.7(88.7–9.6)	86.2 (80.8–90.6)
P. falciparum	56.9 (44.7–68.6)	98.5 (95.7–9.7)	93.2 (81.3–8.6)	86.3 (81.2–90.5)