Table 2.
Results of univariate analysis in the training cohort for predicting LN metastasis
| Variables | Statistics | Odds Ratio (95% CI) | P value |
|---|---|---|---|
| Rad-score (median, interquartile range) | 0 (− 0.45–0.46) | 3.25 (1.99, 5.33) | < 0.0001 |
| Rad-score | |||
| Q1 | 41 (22.8) | 1.0 (reference) | |
| Q2 | 41 (22.8) | 1.89 (0.76, 4.71) | 0.1712 |
| Q3 | 48 (26.8) | 4.03 (1.65, 9.82) | 0.0022 |
| Q4 | 50 (27.8) | 8.57 (3.32, 22.13) | < 0.0001 |
| Age (y, mean ± SD) | 60.5 + 8.8 | 0.97 (0.94, 1.01) | 0.1167 |
| BMI (kg/m2, mean ± SD) | 22.6 + 2.7 | 1.00 (0.90, 1.12) | 0.9987 |
| Sex | |||
| Male | 107 (59.4) | 1.0 (reference) | |
| Female | 73 (40.6) | 0.90 (0.49, 1.63) | 0.7257 |
| CA 19–9 | |||
| < 1000 μg/L | 122 (67.8) | 1.0 (reference) | |
| ≥1000 μg/L | 58 (32.2) | 1.24 (0.66, 2.34) | 0.5011 |
| Location | |||
| Head | 107 (59.4) | 1.0 (reference) | |
| Neck, body and tail | 73 (40.6) | 0.68 (0.37, 1.24) | 0.2062 |
| T grade | |||
| T1 | 22 (12.2) | 1.0 (reference) | |
| T2 | 38 (21.1) | 2.68 (0.91, 7.94) | 0.0746 |
| T3–4 | 120 (66.7) | 2.29 (0.89, 5.86) | 0.0845 |
| Differentiation grade | |||
| Well to moderately | 150 (83.3) | 1.0 (reference) | |
| Poorly to undifferentiated | 30 (16.7) | 0.67 (0.30, 1.47) | 0.3168 |
| Size (mm, median, interquartile range) | 25.01 (19.0–31.6) | 1.01 (0.98, 1.04) | 0.5712 |
| Vascular invasion | |||
| No | 110 (61.1) | 1.0 (reference) | |
| Yes | 70 (38.9) | 1.05 (0.57, 1.92) | 0.8779 |
| Organ invasion | |||
| No | 158 (87.8) | 1.0 (reference) | |
| Yes | 22 (12.2) | 1.21 (0.49, 2.99) | 0.6809 |
| CT-reported LN status | |||
| Negative | 118 (65.6) | 1.0 (reference) | |
| Positive | 62 (34.4) | 2.25 (1.18, 4.28) | 0.0136 |
Data are presented as n (%)
Rad-score radiomics score, LN lymph node, CA19–9 carbohydrate antigen 19–9, CI confidence interval
Patients were categorized into quartiles by radiomics score (Q1 < -0.45, Q2 [−0.45 to 0], Q3 [0 to 0.46], and Q4 ≥ 0.46)