TABLE 2.

DHPS mutations in each patient^a

Patient no.	Sequence of DHPS mutantsb		No. of clones		Therapy for PCP	Treatment results
	Nucleotide	Amino acid	Mutant	Wild type
5	---165GCA CGG 171TCT---	---55Ala Arg 57Ser---	7	3	Pentamidine	Success
6	---165GCA CGG 171TCT---	---55Ala Arg 57Ser---	5	5	Pentamidine	Success
10	---165GCA CGG 171TCT---	---55Ala Arg 57Ser---	10	0	Co-trimoxazole	Failure
13	---165ACA CGG 171TCT---	---55Thr Arg 57Ser---	7	3	Co-trimoxazole	Failure
17 (first BAL fluid specimen)	---165GCA CGG 171TCT---	---55Ala Arg 57Ser---	6	4	Co-trimoxazole	Failure
17 (second BAL fluid specimen)	---165GCA CGG 171TCT---	---55Ala Arg 57Ser---	10	0
18	---165GCA CGG 171TCT---	---55Ala Arg 57Ser---	9	1	Co-trimoxazole	Failure

^aThe mutations were confirmed by cloning and sequencing (10 clones) of each PCR product. 

^bThe nucleotide sequence of the wild type was ¹⁶⁵ACA CGG ¹⁷¹CCT. The amino acid sequence of the wild type was ⁵⁵Ala Arg ⁵⁷Ser.