Table 1.
Lipid metabolism remodeling occurring in cancer cells and cancer related cells.
| Cells | Lipid metabolism | Effects |
|---|---|---|
| Cancer cells | lipogenesis | CD44↑, anoikis resistance |
| Lipid uptake | Initiate metastasis | |
| FAO | Maintain redox homeostasis | |
| Cholesterol esterification | Keep signaling pathway active | |
| TAMs | Lipid uptake | immunosuppression |
| Lipid biosynthesis | IL-6↑, TNF-α↑, ROS↑ | |
| CAFs | Synthesis/catabolism↑ | Secrete FAs |
| Lipid oxidation | CCL2↑, VEGF-A↑, MMP2↑ | |
| CAAs | Release FFAs | Reprogram the metabolism of cancer cells |
CAAs, cancer-associated adipocytes; CAFs, cancer-associated fibroblasts; FAO, fatty acid oxidation; IL-6, interleukin-6; MMP2, matrix metalloproteinases 2; ROS, reactive oxygen species; TAM, tumor-associated macrophage; TNF-α, tumor necrosis factor-α; VEGF-A, vascular endothelial growth factor-A