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. 2021 Nov 4;12(24):7465–7476. doi: 10.7150/jca.62873

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CORO6 activates Wnt signaling by promoting WNT10B expression. (A) Gene set enrichment analysis (GSEA) for RNA-seq data from TCGA-LIHC database. (B) Statistical comparison of WNT1, WNT3 and WNT10B mRNA expression between normal and tumor samples from TCGA-LIHC database by using unpaired Student's t-tests. (C) Detection of WNT10B level via RT-qPCR in Hep3B and SMMC-7721 cells with CORO6 ectopic expression by using unpaired Student's t-tests. (D) TOP-flash/FOP-flash dual luciferase assay for detecting Wnt/b-catenin-driven downstream transcriptional activity. FOP-flash activity was set as a negative control. Unpaired Student's t-tests were performed to test the statistical significance. *P < 0.05; ***P < 0.001; ****P < 0.0001; ns: not significant.