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. 2021 Nov 4;12(24):7465–7476. doi: 10.7150/jca.62873

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CORO6 knockdown inhibits HCC cell growth in vivo by attenuating Wnt pathway. (A) Validation of CORO6 knockdown efficiency by qPCR in Hep3B stable cell lines. Analysis was carried out using unpaired Student's t-tests. (B and C) Confirmation of CORO6 knockdown efficiency by western blotting in Hep3B stable cell lines (B). Analysis was performed by unpaired Student's t-tests (C). (D) Representative images of tumors isolated from mice that are subjected to Hep3B cells with CORO6 depletion. At the top of the image is a scale, the unit is cm. (E and F) Quantification regarding volume of tumors (E) as well as weight (F) in mice (n = 6) that were injected with CORO6 depleted Hep3B cells. Unpaired Student's t-tests were done between the control group (shNC) and CORO6 knockdown groups (shCORO6-1 and shCORO6-2), respectively. (G and H) Western blotting assessment of protein levels of Wnt target genes in tumors formed by Hep3B stable cells with CORO6 knockdown (G). Unpaired Student's t-tests were carried out between the control group (shNC) and CORO6 knockdown groups (shCORO6-1 and shCORO6-2), respectively (H). **P <0.01; ***P < 0.001; ****P < 0.0001.