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. 2021 Oct 28;12(24):7349–7357. doi: 10.7150/jca.61131

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IGFBP3 predicts a poor prognosis in PCa. (A) IHC assay of IGFBP3 expression both in CSPC and CRPC tissues. (B) IGFBP3 expression in TCGA database. (C) qRT-PCR detection of IGFBP3 expression in LNCaP and LNCaP-AI cells. (D) Western blot assay detection of IGFBP3 expression in LNCaP and LNCaP-AI cells. (E) qRT-PCR detection of IGFBP3 expression in LNCaP-AI cells transfected with IGFBP3-specific siRNAs, respectively. (F) Western blot assay of IGFBP3 expression in LNCaP-AI cells transfected with IGFBP3-specific siRNAs, respectively. (G) MTT assay in LNCaP-AI cells. (H) Rescue assay in LNCaP and LNCaP-AI cells. (I) Statistics analysis of rescue assay. (J) Disease free survival in IGFBP3 low expression patients and IGFBP3 high expression patients. For panels B, E, I, One-way ANOVA test; for panel C, two-tailed Student's t-test; for panel G, two-way ANOVA, Sidak's multiple-comparisons test was applied. Error bar indicates the standard deviation (SD). *** P < 0.001, and ****, P < 0.0001.