Table 2.

List of significant mutations that showed different frequencies between patient groups by selected clinical characteristics

Genes	Categorization by clinical variable		p-value
	Without metastasis	With metastasis
	(N=144)	(N=28)
BRAF	9, 6.3%	6, 21.4%	0.019
EPHA6	7, 4.9%	5, 17.9%	0.028
	Without regional lymph node metastasis	With regional lymph node metastasis
	(N=93)	(N=79)
APC	61, 65.6%	63, 79.8%	0.042
ETV4	0, 0%	7, 8.9%	0.004
	Microsatellite stable	Microsatellite instability
	(N=165)	(N=7)
TP53	124, 75.2%	2, 28.6%	0.015
APC	122, 73.9%	2, 28.6%	0.019
	Without lymphovascular invasion	With lymphovascular invasion
	(N=81)	(N=91)
TP53	51, 63.0%	75, 82.4%	0.05
INSR	1, 1.2%	9, 9.9%	0.02
	Without diabetes mellitus	with diabetes mellitus
	(N=134)	(N=38)
ARID1B	10, 7.5%	8, 21.1%	0.031
TNKS2	2, 1.5%	7, 18.4%	0.0004
	BMI ≥ 25	BMI < 25
	(N=45)	(N=127)
RAD50	7, 15.6%	6, 4.7%	0.042
IRS2	4, 8.8%	2, 1.5%	0.041