Table 3.
Prevalence of PD-L1 in EGFR/ALK-mutated NSCLC
| Category, N (%) | TPS < 1% | TPS 1-49% | TPS ≥ 50% | P-value |
|---|---|---|---|---|
| ALK status | 0.9947 | |||
| Rearrangement | 17 (53.1) | 8 (25.0) | 7 (21.9) | |
| Wild type | 261 (52.2) | 128 (25.6) | 111 (22.2) | |
| EGFR mutation status | 0.0017 | |||
| Mutant | 118 (56.2) | 62 (29.5) | 30 (14.3) | |
| Wild type | 139 (50.2) | 62 (22.4) | 76 (27.4) | |
| Joint ALK/EGFR Status | 0.0009 | |||
| ALK+ or EGFR+ | 108 (56.8) | 57 (30.0) | 25 (13.2) | |
| ALK- and EGFR- | 112 (49.8) | 50 (22.2) | 63 (28.0) |
TPS: tumor proportion score; EGFR: epidermal growth factor receptor; ALK: anaplastic lymphoma kinase