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Differences in insulin resistance (a) and insulin release (b) between old (20 months) male and female Hcrt KO and WT mice. Each bar represents the mean value + SEM. a = Significant difference between female WT (+/+) and female KO (−/−) mice and d = significant difference between male WT and KO mice, at the level of p < 0.05*, p < 0.01**.
