Table 1.
Clinical characteristics, laboratory results, and management of cases
| Vaccine | Pfizer 1st dose |
Pfizer 2nd dose |
Oxford/AstraZeneca 1st dose |
|---|---|---|---|
| Age, average (SD) | 39.5 (18.4) | 58.9 (15.8) | 43.3 (8.3) |
| Gender | |||
| Female | 2 | 3 | 3 |
| Male | 2 | 4 | 3 |
| PMH | |||
| Healthy | 2 | 4 | 5 |
| DVT/PE | 1 | 0 | 0 |
| DM + smoker | 0 | 0 | 1 |
| DM + HTA | 1 | 3 | 0 |
| Thrombotic events in relation to individuals received vaccine | |||
| Total: 1/163,000 | 1/257,000 | 1/102,000 | 1/123,000 |
| Type of thrombosis | |||
| Venous | 3 | 3 | 2 |
| Arterial | 1 | 3 | 4 |
| Both | 0 | 1 | 0 |
| Location of thrombosis | |||
| PE | 1 | 1 | 0 |
| DVT | 1 | 2 | 0 |
| Cardiac | 0 | 1 | 1 |
| CVA | 0 | 1 | 3 |
| CVT | 0 | 1 | 1 |
| Limbs | 1 | 0 | 0 |
| DVT + PE | 1 | 0 | 1 |
| DVT + CVA | 0 | 1 | 0 |
|
Average days from vaccine to symptoms (SD) |
13 (5.7) | 14.3 (8.5) | 13.5 (5.8) |
| Nadir platelet (×109/L) | 262 (85.1) | 262 (104.9) | 280.8 (130.5) |
| d-Dimer (ng/ml DDU) | 1542 (1236.6) |
706.5 (598) |
3125 (3283.9) |
| Thrombocytopenia or very high d-Dimer | 0 | 1 | 2 |
| Fibrinogen (g/l) | 2.6 (0.5) | 2.9 (1.5) | 2.7 (0.7) |
| Lupus anticoagulanta | |||
| Positive | 3/3 (100%) | 1/4 (25%) | n.d |
| ACLa | |||
| Positive | 0/3 (0%) | 0/4 (0%) | n.d |
| B2GPa | |||
| Positive | 0/3 (0%) | 0/4 (0%) | n.d |
| Thrombophilia screena | |||
| Positive | 0/3 (0%) | 0/2 (50%) | n.d |
| HIT ELISA assaya | |||
| Positive | n.d | n.d | n.d |
| Treatment | |||
| Rivoraxaban | 0 | 1 | 1 |
| LMWH + warfarin | 3 | 2 | 1 |
| Heparin + rivaroxaban | 1 | 1 | 0 |
| LMW + rivaroxaban | 0 | 1 | 0 |
| ASA + rosuvastatin | 0 | 0 | 2 |
| ASA + heparin + bivalrudin + IVIG | 0 | 1 | 0 |
| None/not available | 0 | 1 | 2 |
| Outcome | |||
| Stable | 4 | 6 | 4 |
| Passed away | 0 | 1 | 2 |
DVT deep vein thrombosis, PE pulmonary embolism, UL upper limb, CVA cerebrovascular accident, CVT cerebral venous thrombosis. ACL anticardiolipin antibody, B2GP beta2 glycoprotein, HITT assay heparin-induced thrombotic thrombocytopenia assay, LMWH low-molecular-weight heparin, IVIG intravenous gammaglobulin, n.d. Not done
aNumbers are expressed as the positive results among those who made the test