Fig. 4.

(top) Pharmacokinetics of the DXP nanoparticles in the plasma of healthy mice. The prodrug (DXP) and the active drug (DXM) were measured in the animals injected with the nanoparticles, and compared with the concentration of DXM in animals injected with the commercial soluble dexamethasone phosphate (DSP). (bottom) Pharmacokinetics parameters of DXM in plasma for DXP-NPs and DSP, calculated with a non-compartmental analysis. C_max maximum plasma concentration of drug, T_max time for drug concentration to reach C_max, C₀ initial concentration, AUC area under the plasma concentration vs time curve, t_1/2 half-life, MRT mean residence time, Cl clearance of drug, and V_d volume of distribution