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. Author manuscript; available in PMC: 2022 Mar 21.
Published in final edited form as: Sci Signal. 2021 Sep 21;14(701):eabf3535. doi: 10.1126/scisignal.abf3535

Fig. 8. Nfkb1 deletion alone does not affect the knee joint phenotypes of middle-aged mice.

Fig. 8.

(A) Representative Safranin O (SAF O) and Fast Green (FG) staining of knee joint sections from wild-type (WT), Nfkb+/− (p50+/−), and Nfkb−/− (p50−/−) mice at 12 months of age. The images in the left column show low-magnification views of the entire joint; the higher magnification views show specific areas within the joint. Scale bars, 50μm. (B to E) Total (B), Safranin O–positive (SafO+) total (C), unmineralized (D), and SafO+ unmineralized (E) tibial articular cartilage areas in knee joints from male and female WT (N = 4 males; N = 4 females), p50+/− (N = 5 males; N = 5 females), and p50−/− (N = 3 males; N = 4 females) mice at 12 months of age, as indicated. All data are shown as mean ± SEM. #p < 0.05 for comparisons between sexes of the same genotype; two-way ANOVA followed by Bonferroni’s multiple comparisons test. Two-way ANOVA followed by Tukey’s multiple comparisons test was performed for comparisons within the same sex.