Table 3.

Associations between other non-differentially regulated serum miRs and the serum hepatocyte death biomarker, keratin 18 in ACHS-I (Anniston, Alabama, 2005–2007, $n=734$).

miR	Keratin 18 ($n=734$)
	M65		M30
	$\mathrm{\beta }\pm \text{SE}$	$p$-Value	$\mathrm{\beta }\pm \text{SE}$	$p$-Value
	Up-regulated miR in other liver disease
miR-148a-3p	$0.15\pm 0.03$	$<0.001$	$0.13\pm 0.03$	$<0.001$
miR-194-5p	$0.12\pm 0.05$	0.01	$0.11\pm 0.04$	0.01
Down-regulated miR in other liver disease
miR-181a-5p	$-0.19\pm 0.04$	$<0.001$	$-0.18\pm 0.04$	$<0.001$
miR-30c-5p	$-0.14\pm 0.03$	$<0.001$	$-0.15\pm 0.03$	$<0.001$
miR-18a-5p	$-0.19\pm 0.05$	$<0.001$	$-0.17\pm 0.05$	$<0.001$
mmu-miR-199a-5p	$-0.20\pm 0.05$	$<0.001$	$-0.21\pm 0.05$	$<0.001$
miR-27b-3p	$-0.17\pm 0.04$	$<0.001$	$-0.09\pm 0.04$	0.04
miR-199a-3p	$-0.13\pm 0.04$	$<0.001$	$-0.11\pm 0.04$	0.004
miR-15b-5p	$-0.06\pm 0.02$	$<0.001$	$-0.07\pm 0.02$	$<0.001$
miR-29a-3p	$0.10\pm 0.03$	0.002	$0.10\pm 0.03$	$<0.001$
miR-130a-3p	$-0.07\pm 0.03$	0.01	$-0.08\pm 0.03$	0.002
let-7i-5p	$-0.07\pm 0.03$	0.02	$-0.06\pm 0.03$	0.04
miR-486-5p	$-0.07\pm 0.03$	0.03	$-0.06\pm 0.03$	0.03
miR-146a-5p	$-0.07\pm 0.03$	0.04	$-0.05\pm 0.03$	0.10
Non-differentially regulated miRs
miR-15a-5p	$-0.00\pm 0.03$	0.93	$-0.03\pm 0.03$	0.22
miR-21-5p	$0.07\pm 0.04$	0.06	$0.04\pm 0.04$	0.29
miR-22-3p	$0.02\pm 0.03$	0.38	$0.02\pm 0.03$	0.36
miR-29c-3p	$0.05\pm 0.04$	0.28	$0.04\pm 0.04$	0.33
miR-185-5p	$-0.03\pm 0.03$	0.30	$-0.03\pm 0.03$	0.32
miR-451a	$0.04\pm 0.03$	0.10	$0.02\pm 0.03$	0.43
miR-222-3p	$-0.05\pm 0.04$	0.18	$-0.07\pm 0.04$	0.06
miR-19a-3p	$-0.01\pm 0.05$	0.81	$0.01\pm 0.05$	0.89
miR-16-5p	$-0.01\pm 0.01$	0.61	$0.00\pm 0.01$	0.93
miR-223-3p	$-0.05\pm 0.04$	0.18	$-0.03\pm 0.04$	0.44
miR-146b-5p	$-0.03\pm 0.05$	0.49	$0.00\pm 0.05$	0.95
miR-92a-3p	$-0.01\pm 0.02$	0.48	$-0.04\pm 0.02$	0.08

Note: Estimates ($\mathrm{\beta }\pm \text{SE}$) were derived from a generalized linear model adjusted for self-reported race, sex, age, BMI, total lipids, total PCBs, and assay plate. $p$-Values are based on $t$-tests with significance set at $p<0.05$. MiRs below the LOD are substituted with the LOD divided by the square root of 2. ACHS-I, Anniston Community Health Survey I; $\mathrm{\beta }$, beta coefficient (see Equation 3a); BMI, body mass index; K18, keratin 18; let, lethal; LOD, limit of detection; M30, K18 measured as a caspase 3-cleaved fragment; M65, K18 measured as a whole protein; miR, microRNA; mmu, Mus musculus; PCB, polychlorinated biphenyl; SE, standard error.