Table 5.

Impact of LT abnormalities on mortality and risk of mechanical ventilation

Predictor	Mortality		Predictor	Mechanical ventilation
	OR (95% CI)	P value		OR (95% CI)	P value
Admission variables
Age	1.076 (1.046–1.107)	<0.001	D-dimer ≥ 1.0	2.486 (1.441–4.288)	0.001
Ch. medical illness	3.563 (1.438–8.832)	0.006	Ferritin ≥ 500	2.322 (1.335–4.039)	0.003
Tn ≥ 0.05 ng/ml	3.347 (1.664–6.733)	0.001	Procalcitonin ≥ 0.5	1.788 (1.011–3.160)	0.046
Bilirubin ≥ 1.0 mg/dl	3.553 (1.524–8.281)	0.003
Procalcitonin ≥ 0.5	2.256 (1.069–4.761)	0.033
Peak variables
Age	1.082 (1.049–1.115)	<0.001	AKI	2.844 (1.572–5.144)	0.001
Chronic medical illness	2.508 (0.964–6.522)	0.059	Elevated peak AST	2.798 (1.304–6.001)	0.008
Elevated peak ALT	0.118 (0.038–0.362)	<0.001	Peak D-dimer ≥ 1.0	3.738 (1.706–8.190)	0.001
Elevated peak AST	9.770 (2.496–38.247)	0.001	Peak procalcitonin ≥ 0.5	3.017 (1.710–5.323)	<0.001
Peak bilirubin ≥ 1.0 mg/dl	4.099 (1.752–9.587)	0.001
Peak Tn ≥ 0.05 ng/ml	3.146 (1.507–6.568)	0.002
Peak procalcitonin ≥ 0.5	2.296 (1.012–5.209)	0.047

Admission markers and mortality: R² = 0.344; AUC = 0.848 (0.796–0.900, P < 0.001).

Admission markers and mechanical ventilation: R² = 0.119; AUC = 0.694 (0.637–0.752, P < 0.001).

Peak markers and mortality: R² = 0.454; AUC = 0.865 (0.819–0.911, P < 0.001).

Peak markers and mechanical ventilation: R² = 0.355; AUC = 0.825 (0.781–0.870, P < 0.001).

AKI, acute kidney injury; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUC, area under the curve; CI, confidence interval; LT, liver test; OR, odds ratio; ULN, upper limit of normal.