. Author manuscript; available in PMC: 2022 Jan 6.

Published in final edited form as: Continuum (Minneap Minn). 2016 Feb;22(1 EPILEPSY):204–226. doi: 10.1212/CON.0000000000000270

TABLE 11-3.

Interactions Between Antiepileptic Drugs and Hormonal Contraception

Antiepileptic Drug	Effect on Hormonal Contraception	Affected by Hormonal Contraception?
Clonazepam, diazepam, ethosuximide, ezogabine, gabapentin, lacosamide, lorazepam, levetiracetam, pregabalin, vigabatrin, zonisamide	None	No
Carbamazepine, clobazam, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, primidone, rufinamide	Decreased ethinyl estradiol levels Decreased progestin levels	Unknown
Topiramate	Decreased ethinyl estradiol levels (dose-dependent effect)	Unknown
Perampanel	Decreased progestin levels	Unknown
Lamotrigine	Decreased progestin levels	Decreased lamotrigine levels (with estrogen-containing contraception)
Valproate	No	Decreased valproate levels (with estrogen-containing contraception)