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The effect of P. gingivalis on vascular smooth muscle cells.
| Stimulus component | Signal pathway | Target | Outcome | References |
|---|---|---|---|---|
| Unknown | TGF-beta/Notch | SMAD3, GO categories, bHLH (HEY1, etc.) | Proliferation | (146) |
| Unknown | Notch1 signaling cascade | HES1, HEY1 | Proliferation | (146) |
| Gingipains | Unknown | S100A9 | Proliferation and transformation |
(145) |
| Gingipains | Unknown | Angpt2, ETS1, Angpt1 | Migration | (151) |
| OMVs | ERK1/2-RUNX2 | Runx2 | Calcification | (156) |
| LPS | Unknown | ALP, Cbfa1, BSP, OPN | Calcification | (161) |
