Comparison 6. Planned subgroup analyses ‐ Immunotherapy versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systemic reaction to field or challenge sting by route of immunotherapy	6	205	Risk Ratio (M‐H, Random, 95% CI)	0.10 [0.03, 0.28]
1.1 Subcutaneous immunotherapy	5	179	Risk Ratio (M‐H, Random, 95% CI)	0.08 [0.03, 0.26]
1.2 Sublingual immunotherapy	1	26	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.01, 6.50]
2 Systemic reaction to field or challenge sting by age	5	175	Risk Ratio (M‐H, Random, 95% CI)	0.10 [0.03, 0.35]
2.1 Under 18 years	1	51	Risk Ratio (M‐H, Random, 95% CI)	0.16 [0.02, 1.21]
2.2 Aged 18 years or over	4	124	Risk Ratio (M‐H, Random, 95% CI)	0.07 [0.01, 0.48]
3 Systemic reaction to field or challenge sting by duration of immunotherapy	6	205	Risk Ratio (M‐H, Random, 95% CI)	0.10 [0.03, 0.28]
3.1 Under 1 year of treatment	4	149	Risk Ratio (M‐H, Random, 95% CI)	0.08 [0.02, 0.28]
3.2 1 to 3 years of treatment	1	5	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3.3 Over 3 years of treatment	1	51	Risk Ratio (M‐H, Random, 95% CI)	0.16 [0.02, 1.21]
4 Systemic reaction to field or challenge sting by insect species	3	95	Risk Ratio (M‐H, Random, 95% CI)	0.07 [0.01, 0.48]
4.1 Honey bee	1	26	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.01, 6.50]
4.2 Wasp	1	5	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.3 Ant	1	64	Risk Ratio (M‐H, Random, 95% CI)	0.04 [0.01, 0.28]
5 Systemic reaction to field or challenge sting by updosing schedule	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Rush or ultrarush	1	5	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
5.2 Weekly or 2‐weekly	4	174	Risk Ratio (M‐H, Random, 95% CI)	0.08 [0.03, 0.26]
6 Systemic adverse reaction to treatment by route of immunotherapy	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1 Subcutaneous immunotherapy	5	255	Risk Ratio (M‐H, Random, 95% CI)	8.16 [1.53, 43.46]
6.2 Sublingual immunotherapy	1	30	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
7 Systemic adverse reaction to treatment by age	5		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
7.1 Under 18 years	0		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
7.2 Aged 18 years or over	5		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
8 Systemic adverse reaction to treatment by duration of immunotherapy	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
8.1 Under 1 year of treatment	4	165	Risk Ratio (M‐H, Random, 95% CI)	8.16 [1.53, 43.46]
8.2 1 to 3 years of treatment	2	120	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
8.3 Over 3 years of treatment	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
9 Systemic adverse reaction to treatment by insect species	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
9.1 Honey bee	1	30	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
9.2 Wasp	2	120	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
9.3 Ant	1	67	Risk Ratio (M‐H, Random, 95% CI)	11.89 [1.65, 85.80]
10 Systemic adverse reaction to treatment by updosing schedule	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
10.1 Rush or ultrarush	2	120	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
10.2 Weekly or 2‐weekly	3	135	Risk Ratio (M‐H, Random, 95% CI)	8.16 [1.53, 43.46]